Ticket to Ride: USA 1910 is a card expansion for the original Ticket to Ride boardgame, winner of the 2004 Spiel des Jahres. It contains 181 large format cards (the same size as Ticket to Ride: Europe and Ticket to Ride: Marklin). This includes 35 new 1910 Destination Tickets, a GlobeTrotter Bonus card for completing the most tickets, 4 Mystery Train Destination Tickets originally provided in the Ticket to Ride: Mystery Train Expansion expansion, and a complete replacement deck of the 141 cards from the original game deck (30 Destination Tickets (4 cards have a reduced value from Ticket to Ride, 110 Train Cards, and 1 Longest Route Bonus Card (Trans America Express)).

• The 1910 Rules: Played as the standard Ticket to Ride, but using only the 1910 Destination Tickets, and GlobeTrotter Bonus card.
• The Big Cities Rules: Played with only the newly identified 35 "Big City" Destination Tickets (15 Standard Tickets, 19 1910 Tickets, and 1 Mystery Train Ticket).
• The Mega Game: featuring all of the game's Destination Tickets and Bonus Cards (30 Standard Tickets, 35 1910 Tickets, 4 Mystery Train Tickets, and both Bonus cards).